The incidence of diabetes has been gradually increasing, not only in middle-aged individuals but also in young individuals.\nHowever, insulin and glucose patterns have not been investigated in apparently healthy young individuals, as they are typically\ngrouped as controls. In this study, we investigated and classified glucose and insulin patterns in healthy young women. Sixtytwo\nnonobese women without metabolic disease were recruited. The subjects underwent a 75 g oral glucose tolerance test\n(OGTT), physical measurements, and a biochemical examination. Two subjects displayed impaired glucose tolerance. The 62\nsubjects were categorized into four patterns by plasma glucose and insulin peak time during OGTT: normal type (n = 39),\ninsulin-late type (n = 11), insulin- and glucose-late type (n = 7), and insulin-very late type (n = 5). OGTT glucose and insulin\nlevels at all time points, insulinogenic index, HOMA-IR, and glucose area under the curve (AUC) significantly differed among\nthe four groups. However, insulin AUC did not significantly differ. We did not detect significant differences in body condition\nor biochemical measurements. Our study demonstrated that some healthy young individuals might have delayed insulin\nsecretion by OGTT. Early detection of altered glucose metabolism might be helpful to improve lifestyle choices and prevent\nprogression to diabetes.
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